Thermal Variations in Osteoporosis After Aclasta® Administration: Case Study

Authors

DOI:

https://doi.org/10.3991/ijoe.v16i10.14635

Keywords:

bone mineral density, diagnosis, osteoporosis, thermography, zaledronic acid

Abstract


Osteoporosis is a metabolic disease characterized by an imbalance between bone formation and resorption, that results in an increasing risk of fracture. The aim of the present study was to investigate changes in the thermal pattern of a 50-year-old female patient after intravenous infusion of zaledronic acid Aclasta® in the treatment of osteoporosis. Thermal images were acquired in orthostatic position of the dorsal region between the lumbar and sacral portions using a FLIR® T530 camera with a thermal sensitivity (NETD) < 30 mK and the sensor array size of 320 x 240 pixels, with an accuracy of ±2% of the reading. The image analysis was performed using the Flir Tools® 6.4 software in order to identify the minimum, average and maximum temperature values in the region of interest; and MATLAB® 2017a software to extract histograms from images. The results present a good agreement between the temperature measurements and the painful symptomatology of the sacroiliac region of the vertebral column affected by the disease. Thermography might be a promising method for monitoring bone healing process.

Author Biographies

Wally auf der Strasse, Universidade Tecnológica Federal do Paraná

Wally auf der Strasse graduated in Physical Education from the Federal University of Paraná (1990), Specialization in Sports Science in Health Promotion from the Pontifical Catholic University of Paraná (1997), Master in Biomedical Engineering from the Federal Technological University of Paraná (2016), PhD student in Biomedical Engineering by the Federal Technological University of Paraná (2017-2021). Ph.D. Sandwich at the Faculty of Engineering, University of Porto (2019-2020). Conferences related to Health and Quality of Life. Researcher at the LAETA Associate Laboratory, biomechanics unit, Foundation for Science and Technology. Reviewer of International Journal of Online and Biomedical Engineering (iJOE) and Biomedical Signal Processing and Control.

Daniel Prado Campos, Universidade Tecnológica Federal do Paraná

Daniel Prado Campos, graduated in Electrical Engineering from the Federal Technological University of Paraná (2014), master in electrical engineering from the Post-Graduate Program in Electrical Engineering (PPGEE) from the Federal Technological University of Paraná (2016) and doctorate in Biomedical Engineering from the Post-Graduation in Electrical Engineering and Industrial Informatics (CPGEI) from the Federal Technological University of Paraná (2019). He is currently a professor of higher education (assistant A) at the Federal Technological University of Paraná (UTFPR). Has experience in Biomedical Engineering, with emphasis on Biological Signal Processing. He works on projects related to the topics of Biosignal Processing and Medical Images, Bioinformatics, Rehabilitation, Assistive Technologies, Automatic Diagnosis, Precision Agriculture, Machine Learning, Pattern Recognition and Data Mining.

Celso Júnio Aguiar Mendonça, Universidade Tecnológica Federal do Paraná

Celso Júnio Aguiar Mendonça, graduated in Medicine from the Federal University of Minas Gerais - UFMG (2001). Medical Residence in Orthopedics and Traumatology, Hospital das Clínicas HC-UFMG (2003-2006). Medical Improvement in Knee Surgery at Hospital das Clínicas HC-UFMG (2006) and Bone Reconstruction and Stretching at Hospital da Baleia in BH - MG (2013). Master in Biomedical Engineering at the Federal Technological University of Paraná - UTFPR (2018). PhD student in Biomedical Engineering at the Federal Technological University of Paraná - UTFPR. Full member of the Brazilian Society of Orthopedics and Traumatology - SBOT. Full member of the ASAMI Committee for Bone Reconstruction and Stretching at SBOT. Titular member of the Brazilian Society of Orthopedic Trauma - SBTO.

Joaquim Mendes, Faculdade de Engenharia da Universidade do Porto

Joaquim Gabriel received the degree in Mechanical Engineering from the Faculty of Engineering (UPorto, 1988), specialization on machine design; a post-graduation degree in Industrial Automation and Process Management; a Master in Industrial Computing, and a PhD in Industrial Electronics from the University of Minho (2003).He was research fellow of JNICT (National Research Association), with the project "Development of Virtual Instrumentation" (1989) and from the Japanese Ministry of Industry EU-STA at Kanagawa Science Park, Japan (1995-97), with the project "Very High Precise Positioning Using Piezoelectric Actuators". In 2012 he was invited researcher at Yokohama City University, Japan, with the development of software for advanced control of a DNA analysis equipment.Since 2003 is assistant professor of FEUP, integrated in the group of automation, instrumentation and control, teaching in the MSc courses of Management and Industrial Engineering, Mechanical Engineering, Electrical Engineering and Computers, Chemistry, Bioengineering; Abel Salazar Institute of Sciences, and Faculty of Dental Medicine.Joaquim Gabriel is researcher in the FCT Unit - UISPA - Integration Unit Systems and Process Automation integrated in INEGI Research Laboratory - Institute of Science and Innovation in Engineering Integrated Mechanical and Industrial Engineering associated with LAETA - Laboratory for Energy, Transport and Space.Main interests: instrumentation, supervisory control and data acquisition -SCADA, industrial automation, medical devices, thermography.

Jamil Faissal Soni, Pontifícia Universidade Católica do Paraná

Jamil Faissal Soni, Graduated in Medicine from the Pontifical Catholic University of Paraná (1988). Medical Residence in Orthopedics and Traumatology at Santa Casa de Misericórdia de São Paulo (1993). Assistant Physician in the Pediatric Orthopedics group at Santa Casa de Misericórdia de São Paulo (1994) Master and Doctorate Faculty of Medical Sciences at Santa Casa de São Paulo. He is currently an Adjunct Professor at the School of Medicine of the Pontifical Catholic University of Paraná, Adjunct Coordinator of the Medical Course at PUCPR, Consultant of the Pediatric Orthopedics Group at the Cajuru University Hospital - PUCPR and the Hospital do Trabalho - UFPR. President of the Brazilian Society of Pediatric Orthopedics.

Percy Nohama, Universidade Tecnológica Federal do Paraná – UTFPR, Curitiba, Paraná, Brazil Pontifícia Universidade Católica do Paraná – PUCPR, Curitiba, Paraná, Brazil

Percy Nohama, currently works in the Graduate Program in Health Technology at Pontifical Catholic University of Paraná (PUCPR) and in the Graduate Program in Electrical Engineering (CPGEI) at the Federal University of Technology - Paraná/Brazil (UTFPR). Prof. Nohama main interest are: Biomedical Engineering, Electronic Instrumentation and Assistive Technologies

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Published

2020-09-18

How to Cite

Strasse, W. auf der, Campos, D. P., Mendonça, C. J. A., Mendes, J., Soni, J. F., & Nohama, P. (2020). Thermal Variations in Osteoporosis After Aclasta® Administration: Case Study. International Journal of Online and Biomedical Engineering (iJOE), 16(10), pp. 82–95. https://doi.org/10.3991/ijoe.v16i10.14635

Issue

Vol. 16 No. 10 (2020)

Section

Papers