Unique and Universal Proteins in Human Genome

Authors

  • Essam Al-Daoud Computer Science Department, Faculty of Information Technology, Zarqa University, Zarqa, Jordan
  • Ghadeer Albesani Computer Science Department, Faculty of Information Technology, Zarqa University, Zarqa, Jordan

DOI:

https://doi.org/10.3991/ijoe.v16i11.16059

Keywords:

Genome, Species, blastp, unique protein, universal protein

Abstract


One of the major troubles with a comparative analysis between human and other species is that only similar amino acid sequences are selected for analysis. To find the connection among the species and find out the unique, the common and the universal proteins, the entire genome of 40 species are compared with the human genome which is utilized as reference genome. More than 11 billion pairwise alignments are performed using blastp. Several findings are introduced in this study, for example, we found 330 unique proteins in human genome and have insignificant hits in all tested genomes, the number of universal proteins in human genome and conserved in all tested species is 82, and there are 180 proteins common in vertebrates genomes, but have insignificant hits in the other tested species. In contrary to the previous studies which use selected set of the genes and do not consider the whole genomes, this study proves that the similarity between human and chimpanzee is only 94.8.

Author Biographies

Essam Al-Daoud, Computer Science Department, Faculty of Information Technology, Zarqa University, Zarqa, Jordan

Essam Al-Daoud is currently a professor and the dean of faculty of information technology at Zarqa University. He received his BSc from Mu’tah University, MSc from Al al-Bayt University and his PhD in Computer Science from University Putra Malaysia. Al Daoud has more than 15 years experience in teaching, research and service in the area of computer security, data science and bioinformatics.

Ghadeer Albesani, Computer Science Department, Faculty of Information Technology, Zarqa University, Zarqa, Jordan

Ghadeer Albesani is currently working at The International Arab Journal of Information Technology (IAJIT). She received her BSc in Software engineering from the Zarqa University in 2014. She received MSc of computer science from Zarqa University in 2019.

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Published

2020-10-05

How to Cite

Al-Daoud, E., & Albesani, G. (2020). Unique and Universal Proteins in Human Genome. International Journal of Online and Biomedical Engineering (iJOE), 16(11), pp. 45–56. https://doi.org/10.3991/ijoe.v16i11.16059

Issue

Vol. 16 No. 11 (2020)

Section

Papers