Brain Dynamics in Response to Intermittent Photic Stimulation in Epilepsy

Authors

  • Tahereh Najafi Department of Electrical, Electronic & Systems Engineering, Universiti Kebangsaan Malaysia, Malaysia https://orcid.org/0000-0003-1692-3558
  • Rosmina Jaafar Dept of Electrical, Electronics & Systems Engineering, Universiti Kebangsaan Malaysia, Bangi, Malaysia
  • Rabani Remli Dept. Medicine, Hospital Canselor Tuanku Muhriz, Universiti Kebangsaan Malaysia,
  • Wan Asyraf Wan Zaidi Dept. Medicine, Hospital Canselor Tuanku Muhriz, Universiti Kebangsaan Malaysia,
  • Kalaivani Chellappan Dept of Electrical, Electronics & Systems Engineering, Universiti Kebangsaan Malaysia, Bangi, Malaysia

DOI:

https://doi.org/10.3991/ijoe.v18i05.27647

Keywords:

Intermittent photic stimulation, Electroencephalography, Epilepsy, support vector machine (SVM), k nearest neighbor (k-NN)

Abstract


Purpose: Routine electroencephalogram (EEG) examinations uses intermittent photic stimulation (IPS) for investigation of the visual cortex EEG responses during resting time. This study aimed to discover brain dynamics effects of IPS in 28 generalized epilepsy patients and 28 healthy subjects. Methodology: Signal processing techniques were used in feature extraction by Fast Fourier transform (FFT), feature dimension reduction by t-test (significant, p<0.05) and classification by nearest neighbor (k-NN) and support vector machine (SVM). Results: The epilepsy group had higher level of amplitude in Theta waves compared to the healthy group. The Alpha waves in the resting time and for all IPS frequencies were observed with lower level of amplitude in healthy subjects compared to the epilepsy group. The k-NN (85.7% accuracy) classifier had the best discrimination of epilepsy from healthy group for resting time versus during IPS at 18 Hz IPS. However, using SVM (75.0% accuracy), IPS at 25 Hz yielded the best discrimination between resting time versus IPS in epilepsy where the healthy group responded similarly in all IPS frequencies. Conclusions: This study shows that IPS at 18 Hz and 25 Hz are suitable IPS frequencies for k-NN and SVM, respectively, to discriminate non-photosensitive generalized epilepsy from normal subjects during interictal.

Author Biography

Rosmina Jaafar, Dept of Electrical, Electronics & Systems Engineering, Universiti Kebangsaan Malaysia, Bangi, Malaysia

ROSMINA JAAFAR (B.Sc, M.Sc, Ph.D) is senior lecturer at Dept. Electrical, Electronics & Systems Engineering, Universiti Kebangsaan Malaysia (UKM). She has attained Ph.D in Electrical, Electronics & Systems Engineering from UKM in 2009, M.Sc in Electronics (Medical Systems) from University of Hertfordshire (UK) in 2000 and B.Sc. in Biomedical Engineering from Case Western Reserve University (USA) in 1991. Her research work revolves around developing healthcare technologies that include biomedical signal processing, imaging, informatics and medical electronics instrumentation.

Covr iJOE Vol. 18 No. 05 (2022)

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Published

2022-04-12

How to Cite

Najafi, T., Jaafar, R., Remli, R., Wan Zaidi, W. A., & Chellappan, K. (2022). Brain Dynamics in Response to Intermittent Photic Stimulation in Epilepsy. International Journal of Online and Biomedical Engineering (iJOE), 18(05), pp. 80–95. https://doi.org/10.3991/ijoe.v18i05.27647

Issue

Vol. 18 No. 05 (2022)

Section

Papers

License

Copyright (c) 2022 Rosmina Jaafar, Rabani Remli, Wan Asyraf Wan Zaidi, Kalaivani Chellappan

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